Pulmonary hypertension (PH) is defined as an increase in the resting mean pulmonary arterial pressure to at least 20 mm Hg on right heart catheterization. People with PH usually experience breathlessness on exertion and may have other symptoms such as fatigue, dizziness, chest discomfort, chest pain, palpitations, cough, pre-syncope, syncope, lower limb oedema and abdominal distension. The current definitions of PH are outlined below.
Haemodynamic definitions of pulmonary hypertension
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Definition
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Haemodynamic characteristics
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Pulmonary hypertension
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mPAP >20 mmHg
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Pre-capillary pulmonary hypertension
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mPAP >20 mmHg
PCWP ≤15mmHg
PVR >2 WU
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Isolated post-capillary pulmonary hypertension
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mPAP >20 mmHg
PCWP>15mmHg
PVR ≤2 WU
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Combined post- and pre-capillary pulmonary hypertension
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mPAP >20 mmHg
PCWP>15mmHg
PVR >2 WU
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Exercise pulmonary hypertension
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mPAP/CO slope between rest and exercise >3mmHg/L/min
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Exercise prescription for patients with pulmonary artery hypertension (PAH) must be individualised based on current medical management, status of PAH-specific medications and other co-morbidities that would impact on the individual's ability to undertake exercise. Current evidence supports exercise for patients with NYHA functional class II, III, and limited in class IV.
Exercise in patients with PAH:
- is effective in improving exercise capacity and health-related quality of life of people with PH
- improves cardiovascular fitness
- improves right and left ventricular function
- reduces pro-inflammatory cytokines
- improves peripheral skeletal muscle function
Evidence currently supports aerobic exercise including walking, exercise bike and treadmill. There is limited evidence to support strength training.
A rating of perceived exertion of 11-13 on the Borg scale, or 3-4 on the modified Borg scale, is recommended to monitor exercise intensity. Interval training regimens are recommended to avoid marked increases in pulmonary pressures with exercise. Alternating upper limb and lower limb exercise may be appropriate to maintain preload. High-intensity exercise, isometrics and Valsalva manoeuvres are to be avoided.
The exercise clinician should monitor:
- Oxygen saturation : Monitor during exercise to maintain SpO2 > 85%. Oxygen should be available during training.
- HR response : If bradycardia is observed during exercise, the patient should cease exercising and should be monitored. Recommencement of exercise should be carried out with caution and medical advice should be sought if necessary.
- Evidence of right HF