Psychosocial Issues Psychosocial Issues

In cases of moderate to severe psychological distress a combination of psychological therapy and medication may be most useful. Where medication may be required it is important to ensure that the individual is referred to a suitably qualified health professional for assessment and consideration for prescribed medication therapy.

Management of depression and anxiety may include drug therapy, exercise, and/or psychotherapy such as cognitive behavioural therapy (CBT), relaxation therapy or stress management approaches.

In cardiovascular disease (CVD) there is no evidence to show which management approach for depression and anxiety is superior in reducing symptoms, and no single approach has yet been shown to reduce cardiovascular events or total mortality.

Psychological therapies can produce small but significant improvements in anxiety and depression, especially if they target “type A” behaviours such as anger and hostility.[#whalley-b-rees-k-davies-p-et-al.-2011]

  • Several antidepressants including selective serotonin reuptake inhibitors (SSRIs) such as sertraline have also been shown to be safe and effective at reducing depressive symptoms in people with coronary heart disease but there are no trials comparing drug and psychological therapies.[#baumeister-h-hutter-n-bengel-j.-2011] The recent UPBEAT study showed that aerobic exercise and sertraline were equally effective at reducing depressive symptoms in patients with coronary heart disease.[#blumenthal-ja-sherwood-a-babyak-ma-et-al.-2012]
  • Combining drug and non-drug treatments may deliver the best results. The COPES study enrolled patients with depression persisting for 3 months or more following an acute coronary syndrome. A stepped approach to depression treatment based on the patient’s individual preferences used a combination of drug treatment (with a choice of antidepressants) and problem-solving therapy combined with additional social support and follow-up. Importantly, in addition to reduced depression, this study showed a reduction in major cardiac events and costs of care.[#davidson-kw-rieckmann-n-clemow-l-et-al.-2010,#ladapo-ja-schaffer-ja-fang-y-et-al.-2012]

Heart failure

In heart failure (HF) two small trials of CBT have shown promising improvements in depressive symptoms although they also included exercise.[#gary-ra-dunbar-sb-higgins-mk-et-al.-2010,#kostis-jb-rosen-rc-cosgrove-n-et-al.-1994] Exercise itself may also alleviate depression in HF, with the largest randomised controlled trial of exercise training in HF (HF-ACTION) showing a small but statistically significant reduction in depression scores in exercisers.[#blumenthal-ja-babyak-ma-oconnor-c-et-al.-2012] Two small trials have also suggested that exercise training may assist anxiety.[#kulcu-dg-kurtais-y-tur-g-et-al.-2007,#koukouvou-g-kouidi-e-iacovides-a-et-al.-2004]

Although several small trials have suggested that antidepressants benefit HF patients,[#echols-mr-jiang-w.-2011] the largest study of drug therapy is the SADHART-CHF study which randomised 469 adults with HF and clinical depression to sertraline or placebo for 12 weeks. Sertraline did not significantly improve depression symptoms compared with placebo, with significant improvements seen in both groups.[#oconnor-cm-jiang-w-kuchibhatla-m-et-al.-2010] The study involved fortnightly nurse telephone, home or clinical follow-up, which may have provided a level of support and intervention to account for the improvement in both groups. Preliminary results of a larger and longer duration trial (MOOD-HF) suggest that SSRI is no better than placebo.[#angermann-c-gelbrich-g-stoerk-s-et-al.-2015]

Some examples of psychological therapies that may be considered include:

  • Cognitive Behaviour Therapy (CBT)
    CBT focuses on identifying and changing unhelpful thinking and behavioural processes in order to improve emotional and behavioural problems. The modern "third wave" of CBT merges CBT with mindfulness to produce Mindfulness-Based CBT, Acceptance and Commitment Based Therapy, and Metacognitive Therapy. For more complex personalities, CBT is sometimes integrated with other therapies: e.g., Schema Focused Therapy or Cognitive Analytic Therapy.
  • Psychodynamic therapy
    This aims to provide the individual with a better understanding of themselves. The therapy helps identify common and repeating interpersonal patterns and assists the individual to develop more productive patterns of relating to self and to others. Chris Allan's blog has a range of relevant links.
  • Narrative therapy
    Narrative therapy, (see www.dulwichcentre.com.au), explores the dominant and alternative stories of the individual’s life. Narrative therapists deconstruct the dominant, powerful stories by ‘externalising’ the issue as the problem and not as part of the person’s essential being. They assist the individual to co-construct alternative stories that can bring a new sense of identity and a new future.
  • Relaxation therapy
    Relaxation therapy may include breathing exercises, visualisation activities, progressive muscle relaxation, tai chi, meditation and mindfulness exercises. Relaxation therapy incorporated into traditional cardiac interventions reduces perceived stress, and this reduction is believed to decrease the progression of cardiac disease.[#neve-a-alves-a-ribeiro-f-et-al.-2009]
  • Whalley B, Rees K, Davies P, et al. Psychological interventions for coronary heart disease. Cochrane Database of Systematic Reviews 2011; Issue 8 art no :CD002902. DOI:10.1002/14651858. CD002902.pub3.

    whalley-b-rees-k-davies-p-et-al.-2011
  • Baumeister H, Hutter N, Bengel J. Psychological and pharmacological interventions for depression in patients with coronary artery disease. Cochrane Database of Systematic Reviews 2011; Issue 9 art no :CD008012. DOI:10.1002/14651858. CD0000812.pub3.

    baumeister-h-hutter-n-bengel-j.-2011
  • Blumenthal JA, Sherwood A, Babyak MA, et al.Exercise and pharmacological treatment of depressive symptoms in patients with coronary heart disease: results from the UPBEAT (Understanding the Prognostic Benefits of Exercise and Antidepressant Therapy) study. J Am Coll Cardiol 2012;60:1053-63.

    blumenthal-ja-sherwood-a-babyak-ma-et-al.-2012
  • Davidson KW, Rieckmann N, Clemow L, et al. Enhanced depression care for patients with acute coronary syndrome and persistent depressive symptoms: Coronary Psychosocial Evaluation Studies randomized controlled trial. Arch Intern Med 2010;170:600-608.

    davidson-kw-rieckmann-n-clemow-l-et-al.-2010
  • Ladapo JA, Schaffer JA, Fang Y, et al. Cost-effectiveness of enhanced depression care after acute coronary syndrome: results from the Coronary Psychosocial Evaluation Studies randomized controlled trial. Arch Intern Med 2012;172:1682-1684.

    ladapo-ja-schaffer-ja-fang-y-et-al.-2012
  • Gary RA, Dunbar SB, Higgins MK, et al. Combined exercise and cognitive behavioural therapy improves outcomes in patients with heart failure. J Psychosom Res 2010;69:119-131.

    gary-ra-dunbar-sb-higgins-mk-et-al.-2010
  • Kostis JB, Rosen RC, Cosgrove N, et al. Neuropharmacologic therapy improves functional and emotional status in congestive heart failure. Chest 1994;106:996-1001.

    kostis-jb-rosen-rc-cosgrove-n-et-al.-1994
  • Blumenthal JA, Babyak MA, O’Connor C, et al. Effects of exercise training on depressive symptoms in patients with chronic heart failure. The HF-ACTION randomized trial. JAMA 2012;308:465-474.

    blumenthal-ja-babyak-ma-oconnor-c-et-al.-2012
  • Kulcu DG, Kurtais Y, Tur G et al. The effect of cardiac rehabilitation on quality of life, anxiety and depression in patients with congestive heart failure. A randomized controlled trial, short-term results. Eura Medicophys. 2007;43(4):489-497.

    kulcu-dg-kurtais-y-tur-g-et-al.-2007
  • Koukouvou G, Kouidi E, Iacovides A, et al. Quality of life, psychological and physiological changes following exercise training in patients with chronic heart failure. J Rehabil Med 2004;36:36-41.

    koukouvou-g-kouidi-e-iacovides-a-et-al.-2004
  • Echols MR, Jiang W. Clinical trial evidence for treatment of depression in heart failure. Heart Fail Clin 2011;7:81-88.

    echols-mr-jiang-w.-2011
  • O’Connor CM, Jiang W, Kuchibhatla M, et al. Safety and efficacy of sertraline for depression in patients with heart failure. J Am Coll Cardiol 2010;56:692-699.

    oconnor-cm-jiang-w-kuchibhatla-m-et-al.-2010
  • Angermann C, Gelbrich G, Störk S, et al. Effects of selective serotonin re-uptake inhibition on mortality, morbidity and mood in depressed heart failure patients. American College of Cardiology 2015 Scientific Sessions; March 16, 2015; San Diego, CA. Abstract 414-05.

    angermann-c-gelbrich-g-stoerk-s-et-al.-2015
  • Neve A, Alves A, Ribeiro F, et al. The effect of cardiac rehabilitation with relaxation therapy on psychological, hemodynamic and hospital admission outcome variables. J Cardiopulm Rehabil Prev 2009;29:304-309.

    neve-a-alves-a-ribeiro-f-et-al.-2009